Update on the Surgical Management of Fuchs Endothelial Corneal Dystrophy
نویسندگان
چکیده
منابع مشابه
Fuchs endothelial corneal dystrophy: current perspectives.
Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet's membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress ...
متن کاملSLC4A11 mutations in Fuchs endothelial corneal dystrophy.
The endothelial (posterior) corneal dystrophies, which result from primary endothelial dysfunction, include Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD) and congenital hereditary endothelial dystrophy (CHED). Mutations in SLC4A11 gene have been recently identified in patients with recessive CHED (CHED2). In this study, we show that heterozygous mut...
متن کاملCorneal Hydration Control in Fuchs' Endothelial Corneal Dystrophy
Purpose To assess corneal hydration control across a range of severity of Fuchs' endothelial corneal dystrophy (FECD) by measuring the percent recovery per hour (PRPH) of central corneal thickness after swelling the cornea and to determine its association with corneal morphologic parameters. Methods Twenty-three corneas of 23 phakic FECD patients and 8 corneas of 8 healthy control participant...
متن کاملThe Genetic Basis of Fuchs Endothelial Corneal Dystrophy
Fuchs endothelial corneal dystrophy (FECD) is characterized by pleomorphic, attenuated, dysfunctional, and degenerated corneal endothel ium together with progressive formation of corneal guttae. The condition may show familial clustering but is usually sporadic and predominantly affects women. Family based studies have mapped late onset FECD susceptibility to 13ptel-13q12.13 and 18q21.2-q21.32....
متن کاملFuchs Endothelial Dystrophy: Pathogenesis and Management
■ Fuchs endothelial dystrophy (FED) is a progressive disorder of the corneal endothelium with accumulation of focal excrescences called guttae and thickening of Descemet’s membrane, leading to stromal edema and loss of vision ■ The inheritance of FED is autosomal dominant, with modifiers such as increased prevalence in the elderly and in females ■ Corneal endothelial cells are the major “pump” ...
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ژورنال
عنوان ژورنال: Ophthalmology and Therapy
سال: 2020
ISSN: 2193-8245,2193-6528
DOI: 10.1007/s40123-020-00293-3